Program

Page Contents

Epidemiology/Impact

Minisymposium on Zoonotic Origins of Human Respiratory Viruses

Virology and Diagnostics

Pathogenesis

Clinical

Vaccinology and Prevention

Vaccinology and Prevention (continued)

Antivirals and Therapeutics

February 28, 2008

11:00 am	Registration desk opens
2:00-2:05 pm	Welcoming Frederick Hayden, GIP/EPR/CDS, World Health Organization, Geneva, Switzerland
2:05-2:10 pm	Opening Remarks & Introduction of Keynote Malik Peiris, Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
2:10-2:55 pm	Keynote Speaker: Why Influenza Kills and will Kill Again Yoshihirio Kawaoka, University of Wisconsin-Madison & The University of Tokyo, USA & Japan
Session I: Epidemiology/Impact
3:25 am	Disease Burden of Respiratory Disease John V. Williams, Vanderbilt University, Nashville, Tennessee, USA
3:25-3:55 pm	The Role of Vaccines for RSV: View From the Developing World James D. Nokes, Wellcome Trust, Kilifi, Kenya
3:55-4:25 pm	Disease Burden of Pneumonia in China Nan-Shan Zhong, Guangzhou Institute of Respiratory Diesease, Guangzhou Medical College, China
4:25-4:55 pm	COFFEE BREAK Sponsored by The Macrae Group
4:55-5:25 pm	Transmission of Influenza Viruses - Routes for Containment or Mitigation To be determined
5:25-5:55 pm	Confronting Emerging Viral Pathogens Paul Tambyah, Infectious Diseases, University of Singapore Hospital, Singapore
\5:55-6:10 pm	Recent Outbreaks of Diverse Species B Respiratory Adenoviruses in Military Recruits and Civilians David Metzger, Department of Respiratory Disease Research, Naval Health Research Center, San Diego, California, USA
6:10-6:55 pm	Late Breaker Abstracts (3x15 min)
7:00-8:30 pm	Welcoming Reception

7:30-8:30 am	CONTINENTAL BREAKFAST
Session II: Minisymposium on Zoonotic Origins of Human Respiratory Viruses
Chairs: Albert Osterhaus, Erasmus MC, Rotterdam, The Netherlands
8:30-9:00 am	Difficulties and Opportunities for Treatment of H5N1 Infection Menno de Jong, Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
9:00-9:30 am	Origins of Zoonotic Pathogens: SARS Coronavirus and Avian Flu H5N1 Malik Peiris, Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
9:30-10:00 am	The Next Nipahvirus, A Pandemic Threat? Paul Rota, CDC, Atlanta, Georgia, USA (invited)
10:00-10:30 am	Panel Discussion Albert Osterhaus, Menno de Jong, Malik Peiris, Paul Rota
10:30-11:00 am	Oral Presentations (2x15 min)
11:00-11:30 am	COFFEE BREAK
11:30-12:00 pm	Oral Presentations (2x15 min)
12:00-3:30 pm	MID-DAY BREAK
Session III: Virology and Diagnostics
3:30-4:30 pm	Special Lecture: Pathogen Discovery W. Ian Lipkin, MSPH/Jerome L. and Dawn Greene Infectious Disease Lab, Columbia University, New York, New York, USA
4:30-5:00 pm	Update Status of POC Diagnostics for Influenza Nancy Cox, DHHS/NCID/VR/I, Centers for Disease Control, Atlanta, Georgia, USA
5:00-5:15 pm	Global Distribution of New Human Rhinovirus Strains Wai-Ming Lee, University of Wisconsin, Madison, Wisconsin, USA
5:15-5:30 pm	Oral Presentation
5:30-5:50 pm	Pre-Clinical Papers Literature Review – SARS & Influenza Malik Peiris, Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
5:50-6:10 pm	Pre-Clinical Papers Literature Review – Other Viruses James Gern, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
6:10-6:45 pm	Poster Review Albert Osterhaus, Erasmus MC, Rotterdam, The Netherlands
7:00-8:30 pm	Poster Session Wine & Cheese Reception

7:00-8:00 am	CONTINENTAL BREAKFAST
Session IV: Pathogenesis
8:00-9:05 am	Flu Receptors Ian Wilson, The Scripps Research Institute, La Jolla, California
9:05-9:30 am	Asthma/COPD Mechanisms Sebastian Johnston, Imperial College, London, UK
9:30-9:55 am	Pathogenesis of Measles Revisited Albert Osterhaus, Erasmus MC, Rotterdam, The Netherlands
9:55-10:20 am	Host Factors that Modify the Severity of Viral Respiratory Illnesses in Children James Gern, University of Wisconsin, Madison, Wisconsin
10:20-10:50 am	COFFEE BREAK
10:50-11:15 am	Role of Acute Respiratory Infections Causing Chronic Disease Eric Simoes, University of Colorado Health Science Center, Children’s Hospital, Denver, Colorado
11:15-11:30 am	Th1 Lynmphocyte Responses in Human and Mouse Experimental Rhinovirus Disease Models Nathan Bartlett, Imperial College, London, United Kingdom
11:30-11:45 am	Proteinase-activated Receptor (PAR)-mediated Inflammatory Cell Responses of RSV-infected Human Lung Epithelial Cells can be Counteracted by Peroxisome-proliferator Activated Receptor-g (PPARg) Agonists Wolfgang Koenig, Oho von Guericke University, Magdeburg, Germany
11:45-12:00 pm	Transcriptional Regulation of Type I Interferon-ß and Type III Interferon-λs in Bronchial Epithelial Cells. Common Role of the Transcription Factor IRF-3 Michael Edwards, Imperial College, London, United Kingdom
12:00-12:15 pm	Transmission of Influenza Virus is More Efficient by Droplet Spread than by Fomites Samira Mubareka, Mount Sinai School of Medicine, New York, New York, USA
Session V: Clinical
12:15-12:40 pm	Literature Review: Clinical Papers To be determined
12:40-3:45 pm	MID-DAY BREAK
3:45-4:10 pm	Clinical Manifestations of Respiratory Viruses in Children Terho Heikkinen, Turku University Hospital, Turku, Finland
4:10-4:35 pm	Non ventilatory Treatment for ARDS/ALI To be determined
4:35-4:50 pm	Abnormalities In Lung Function at Age 6 Years Differ in Children Who Wheezed with RV vs. RSV in Early Childhood Douglas DaSilva, Imperial College, London, United Kingdom
4:50-5:05 pm	Influenza Patients with Systemic Co-morbid Illnesses have Persistently Higher Viral Loads - Implications for Therapeutic Intervention Nelson Lee, The Chinese University of Hong Kong, Hong Kong SAR, China
Session VI: Vaccinology and Prevention
5:05-5:50 pm	Strategies to Enhance Global Access to Vaccines Frederick Hayden, GIP/EPR/CDS, World Health Organization, Geneva, Switzerland
5:50-6:15 pm	Pandemic Preparedness: Japanese Approach to Vaccines and Antivirals Masato Tashiro, National Influenza Laboratory, Tokyo, Japan
6:15-6:45 pm	COFFEE BREAK
6:45-7:10 pm	Host Factors That Influence Vaccine Responses Institute for Child Health Research, University of Western Australia, Perth, Australia (to be determined)
7:10-7:40 pm	The Role of Adjuvants in Pandemic Preparedness Albert Osterhaus, Erasmus MC, Rotterdam, The Netherlands
7:40-8:10 pm	Live Attenuated Influenza Vaccine in Adults. Multi-year Comparison with TIV? Arnold Monto, University of Michigan School of Public Health, Ann Arbor, Michigan, USA

7:00-8:00 am	CONTINENTAL BREAKFAST
Session VI: Vaccinology and Prevention (continued)
8:00-8:15 am	Clinical Trial Results with Vero Cell Derived Whole Virus Clade 1 and Clade 2 H5N1 Pandemic Influenza Vaccines Hartmut Ehrlich, Baxter Bioscience, Vienna, Austria
8:15-8:30 am	Shedding of Live Vaccine Virus, Comparative Safety, and Influenza-Specific Antibody Responses after Administration of Live Attenuated and Inactivated Trivalent Influenza Vaccines to HIV-Infected Children Myron Levin, University of Colorado School of Medicine, Denver, Colorado, USA
8:30-8:45 am	Safety and Immunogenicity of an AS Adjuvanted H5N1 Prepandemic Influenza Vaccine. A Phase III Study in a Large Population of Asian Adults Thongcharoen Prasert, Microbiological Unit, Siriraj Hospital, Mahidol University, Bangkok, Thailand
Session VII: Antivirals and Therapeutics
8:45-9:10 am	What is New with RSV Prophylaxis Jesse Groothuis, ID & Vaccines, MedImmune Inc., Gaithersburg, Maryland, USA
9:10-9:40 am	Influenza Antivirals in H5N1 Disease - Animal Model Elena Govorkova, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
9:40-10:10 am	Antiviral Post Exposure Prophylaxis and Long Term Prophylaxis Usage in Flu Outbreaks: H7N1 Case Study in Wales Jonathan Van Tam, Health Protection Agency, UK
10:10-11:30 am	Epidemiology, Management and Treatment of Human H5N1: Experiences from the Middle and Far East Chair: Menno de Jong, Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam 10:30 The Egyptian Experience, Abdel-Nasser Abdel-Ghafar, Ministry of Health and Population, Egypt 10:50 The Indonesian Experience, Endang R. Sedyaningsih, National Institute of Health Research and Development, Ministry of Health, Indonesia 11:10 The Recent Vietnamese Experience, Heiman F. L. Wertheim, Oxford University Clinical Research Unit, National Institute of Infectious and Tropical Diseases, Hanoi, Vietnam (invited)
11:30-12:00 pm	COFFEE BREAK
12:00-12:20 pm	Update on Peramivir W. James Alexander, Senior Vice President, Clinical and Regulatory Operations and Chief Medical Officer, BioCryst Pharmaceuticals, Inc., Birmingham, Alabama, USA (invited)
12:20-12:40 pm	Update for Influenza: T-705 Compound Yousuke Furuta, Toyama Chemical Co., Ltd, Tokyo, Japan (invited)
12:40-1:10 pm	Update on Antivirals for Respiratory Viruses Jane Ryan, Biota Holdings Limited, Melbourne, Australia
1:10-1:40 pm	Oral Presentations (2x15 min)
1:40-2:10 pm	Closing Remarks - Frederick Hayden, GIP/EPR/CDS, World Health Organization, Geneva, Switzerland - Malik Peiris, Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China - James Gern, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USARobert Webster & Frederick Hayden

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Program

Page Contents

Session I: Epidemiology/Impact

Session II: Minisymposium on Zoonotic Origins of Human Respiratory Viruses

Session III: Virology and Diagnostics

Session IV: Pathogenesis

Session V: Clinical

Session VI: Vaccinology and Prevention

Session VI: Vaccinology and Prevention (continued)

Session VII: Antivirals and Therapeutics

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