Sections

Home

Personal tools

You are here: Home → 2009 Symposia → XI International Symposium on Respiratory Viral Infections → Oral abstracts → Maternal Influenza immunization and Birth Weights: A Randomized Trial in Bangladesh

The Macrae Group LLC

Lymphopenia in H5N1 patients in Northern Viet Nam: kinetics and subsets
Title of Contribution: A prospective cohort study of the seasonality and burden of pediatric influenza in Nicaragua
Characterisation of Influenza H1N1 viruses resistant to Oseltamivir
Paradoxical Generalized Decrease of Influenza-Specific T-Cell Responses in HIV-Infected Children after Administration of Inactivated Influenza Vaccine and Sporadic Decrease after Live Attenuated Influenza Vaccine
The relation between viral shedding and clinical course in natural influenza infections
Development of a Multiplexed Luminex xMap Assay for Serotype Specific Detection of Five Human Adenoviruses that cause Respiratory Illness.
Preexisting immunity to diverse respiratory adenovirus serotypes among young adults in the United States, 1998-2008
The PB1-F2 protein of influenza A virus modulates the early immune response leading to increased pathogenesis in the mouse model.
Genetic clustering of human rhinovirus strains in infants with severe bronchiolitis
Cross-reactive immunity of Influenza A/H5N1 strains in mice & humans
Ocular infection of mice with influenza A (H7) viruses: A site of primary virus replication and spread to the respiratory tract.
Nature and Impact of Influenza Antigen Specific T Cell Responses on Disease in an In Vivo Human Challenge Model.
Prospective Cohort Study of Avian Influenza Transmission in Cambodia and Thailand
Safety and Efficacy of Multiple-Day Treatment with Intravenous Peramivir or Oral Oseltamivir in Hospitalized Adults with Acute Influenza
Oseltamivir prophylaxis significantly reduces the incidence of seasonal influenza infection in immunocompromized patients
Anti-Influenza Serum and Mucosal Antibody Responses after Administration of Live Attenuated or Inactivated Influenza Vaccines to HIV-Infected Children
The Global Emergence and Evolution of Adamantane Resistant A/H3N2 Influenza Viruses
Maternal Influenza immunization and Birth Weights: A Randomized Trial in Bangladesh
Cystus052 a new compound against seasonal and pandemic influenza virus
Safety and Immunogenicity of an AS03-adjuvanted H5N1 Prepandemic Influenza Vaccine –A Phase III Study in Thai Population
An Early Report from a Randomized Controlled Trial of Nonpharmaceutical Interventions to Reduce Household Influenza Transmission; the Bangkok HITS Study
Combinations of immunomodulators and specific antivirals: A new treatment paradigm for Influenza
Antiviral Control of Influenza in Aged-Care facilities in Sydney region over 3 seasons
Rhinovirus infection augments recruitment of Th2 allergen specific T cells to the airway
Vaccination approaches to combat human metapneumovirus lower respiratory tract infections
Clinical features of human influenza A(H5N1) infection in Vietnam: 2004-2006
Oseltamivir pharmacokinetics in Vietnamese patients with severe human and H5N1 avian influenza.

Maternal Influenza immunization and Birth Weights: A Randomized Trial in Bangladesh

Session VI – M.C. Steinhoff

Title of Contribution: Maternal Influenza immunization and Birth Weights:
A Randomized Trial in Bangladesh

Author(s): M. Steinhoff , K. Zaman, E. Roy, S. Omer, S. E. Arifeen, R. Raqib,

Affiliation(s): Johns Hopkins Univ., and ICDDRB, Dhaka, Bangladesh

Abstract:
Background: Influenza immunization is recommended during pregnancy, but has been little studied. We estimated the effect of maternal flu immunization on infant birth weight in Dhaka, Bangladesh, taking into account the antigenic similarity of local flu viruses with the study flu vaccine. We used the clinical effectiveness of study flu vaccine against febrile respiratory illness as a proxy for the degree of antigenic match.

Design/Methods: We conducted a blinded RCT of 3rd trimester immunization of 340 mothers randomized to either flu vaccine or pneumococcal vaccine (control). (See NEJM 2008;359:1555) Study flu vaccine (WHO S. Hemisphere formulation, 2004) was effective against febrile respiratory illness from Feb thru Oct 2005. We compared birth weights in the 2 groups of mothers from Feb to June 2005 (matched vaccine), compared to births from Aug to Jan 2004, when local flu viruses did not match flu vaccine antigens (non-matched vaccine)

Preliminary Results: Births occurred from Aug 04 thru June 05. For infants in utero during circulation of non-matched flu viruses, mean birth weights were 3,077g in the flu vaccine group vs. 3,053g in the control vaccine group (p=0.70) . During circulation of flu viruses which matched the vaccine, the mean birth weight of 59 infants in the flu group was 3,186g vs. 2,972g in 57 control infants; a difference of +215g or +7% (p=0.018).

Conclusion: During circulation of flu viruses which matched the study vaccine, flu-immunized mothers delivered babies with statistically significantly greater birth weights, compared to mothers who received control vaccine. These unique RCT data from a limited-resource region suggest 1) prevention of influenza infection in pregnancy enhances fetal growth. These data also 2) imply flu infection in late pregnancy may reduce birth weight. We are planning a new RCT of maternal influenza immunization to refine these estimates.

Supported by the Bill and Melinda Gates Foundation, USAID, Wyeth Pharmaceuticals, Thrasher Research Fund, Aventis Pasteur, the International Centre for Diarrheal Disease Research, and the Johns Hopkins Bloomberg School of Public Health, USA.

Document Actions

« September 2010 »

Abstract format

(Word Document)

title
author(s)
author(s) affiliation(s)
abstract

Typed as follows

single-space
Times New Roman or Arial
11 or 12 point
1 page
1.5 inch (3.8 cm) top and bottom margins

Provide the details

presenting author
address/email address
session for abstract consideration